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Allergology · Skin allergies

Acute allergic skin reactions

Urticaria, contact eczema, swelling or a drug-induced rash: acute allergic skin reactions appear suddenly after contact with a substance, a food or a medicine. Find out how to recognise them and when to seek medical advice promptly.

Written by Dr A. Turcarelli, dermatologist and allergist Updated 5 January 2026 5 min read

Introduction

They are usually linked to a rapid release of histamine and can range from mild forms to more severe reactions that need urgent treatment.

Symptoms

  • Hives (raised red patches that come and go)
  • Intense itching
  • Localised swelling (eyelids, lips, face)
  • Widespread redness
  • Burning sensation in the skin
  • Rapid spread of the lesions
  • Sometimes: feeling generally unwell or other associated signs

Causes

Food allergies
Drug allergies
Insect stings or bites
Contrast agents
Latex
Exposure to certain environmental allergens
Physical exercise combined with an allergen (particular cases)

Diagnosis

  1. Detailed history (timing, trigger)
  2. Skin examination
  3. Looking for signs of severity
  4. Allergy tests at a later date (once symptoms have resolved)
  5. Ruling out other, non-allergic causes

Treatments

Antihistamines as first-line treatment
Short course of oral corticosteroids if needed
Clinical monitoring
Adrenaline auto-injector for severe reactions
Hospital admission if there are systemic signs

Management

Identify the exact cause of the reaction

Prevent recurrences

Assess the risk of severe forms

Tailor preventive measures

Frequently asked questions

Consultation for acute allergic skin reactions

Consultation with a confirmed diagnosis and a written treatment plan.

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