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Dermatology · Viral skin infections

Cold sores (herpes labialis)

Herpes labialis, commonly known as a “cold sore”, is a common viral infection mainly caused by herpes simplex virus type 1 (HSV-1). After a first infection that often goes unnoticed, the virus remains dormant in the body and can reactivate from time to time (fever, sun, stress, tiredness), causing painful blisters around the mouth.

Written by Dr A. Turcarelli, dermatologist and allergist Updated 4 January 2026 6 min read

Herpès labial

Introduction

Herpes labialis, commonly known as a ‘cold sore’, is a common viral infection caused by herpes simplex virus type 1 (HSV-1). After a first infection, which often goes unnoticed, the virus remains dormant (latent) in the body and can reactivate repeatedly, causing characteristic lesions around the mouth.

Symptoms

  • Local tingling, burning or tightness (prodromal phase)
  • Clusters of blisters on a red base on the lips or around the mouth
  • Blisters break open and crust over
  • Pain or cosmetic discomfort
  • Possible local swelling
  • Heals on its own in 7 to 10 days
  • Recurrences vary from person to person

Causes

Infection with herpes simplex virus type 1 (HSV-1)
Transmission through direct contact (saliva, kissing, contaminated objects)
Reactivation encouraged by
Stress Tiredness Fever Sun exposure Lowered immunity
Stress
Tiredness
Fever
Sun exposure
Lowered immunity

Diagnosis

  1. Clinical diagnosis in most cases
  2. No further tests needed routinely
  3. Viral swab (PCR) reserved for atypical or severe forms
  4. Differential diagnosis with: Impetigo Contact dermatitis Mouth ulcers around the lips
  5. Impetigo
  6. Contact dermatitis
  7. Mouth ulcers around the lips

Treatments

Aciclovir creams (mild forms)
Oral valaciclovir or aciclovir (severe or recurrent forms)
Apply early, at the first signs
Sun protection for the lips
Avoid touching or scratching the lesions
Low-level laser therapy (LLLT) in some specialist treatment settings
Photobiomodulation to speed up healing and reduce pain

Management

Dermatological care for frequent recurrences or severe forms

Patient education on recognising early signs

Prevention of recurrences through sun protection

Support if there is a cosmetic or professional impact

Frequently asked questions

See us about cold sores

Consultation with a confirmed diagnosis and a written treatment plan.

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