secretariat.drturcarelli@gmail.com +352 49 80 50 50, avenue de la Liberté, L-1930 Luxembourg-Gare
Dermatology · Viral skin infections

Hand, foot and mouth disease

Hand, foot and mouth disease is a contagious, generally mild viral infection that is common in young children but can also occur in adults. Caused by enteroviruses (mainly coxsackievirus A16, coxsackievirus A6 and enterovirus 71), it combines a mild fever, painful sores in the mouth and a rash of small blisters on the hands and feet.

Written by Dr A. Turcarelli, dermatologist and allergist Updated 4 January 2026 6 min read

Maladie main-pied-bouche

Introduction

In most cases it clears up on its own.

Symptoms

  • Mild fever
  • Feeling generally unwell, tiredness
  • Blisters or small red spots on the palms of the hands
  • Similar spots on the soles of the feet
  • Painful ulcers or blisters in the mouth
  • Pain when swallowing
  • Possible mild itching
  • Irritability in children
  • Possible later peeling of the fingers or nails

Causes

Infection with enteroviruses (coxsackievirus A16, A6, EV71, etc.)
Transmission
By direct contact Through the respiratory route Via contaminated hands or objects
By direct contact
Through the respiratory route
Via contaminated hands or objects
Highly contagious in group settings (nurseries, schools)
Incubation
3 to 7 days

Diagnosis

  1. Diagnosis is essentially clinical
  2. Suggestive epidemic context
  3. No further tests needed routinely
  4. Viral PCR reserved for atypical or complicated forms
  5. Differential diagnosis with: Chickenpox Herpes Isolated mouth ulcers (aphthous ulcers)
  6. Chickenpox
  7. Herpes
  8. Isolated mouth ulcers (aphthous ulcers)

Treatments

Fever-reducing medicines if there is a fever
Painkillers for mouth pain
Soothing mouth rinses or gels
Rest
Plenty of fluids
Cold or lukewarm food to limit pain
Strict hygiene measures to limit spread
No specific dermatological technology indicated
Simple clinical follow-up

Management

Dermatological or paediatric care

Information and reassurance for parents or the patient

Monitoring of unusual forms in adults

Temporary exclusion from nursery, school or group settings during the acute phase

Frequently asked questions

See us about hand, foot and mouth disease

Consultation with a confirmed diagnosis and a written treatment plan.

Call Book an appointment