secretariat.drturcarelli@gmail.com +352 49 80 50 50, avenue de la Liberté, L-1930 Luxembourg-Gare
Dermatology · Viral skin infections

Erythema infectiosum (parvovirus B19)

Erythema infectiosum, also known as “fifth disease” or slapped cheek syndrome, is a common viral infection caused by parvovirus B19. It mainly affects school-age children but can also affect adults, in whom it sometimes causes joint pain. It appears as bright red cheeks (the “slapped cheek” look), followed by a lace-like rash on the trunk and limbs. A mild fever may come first. Harmless in the vast majority of cases, it clears up on its own. Particular care is needed, however, during pregnancy and in people with weakened immunity.

Written by Dr A. Turcarelli, dermatologist and allergist Updated 17 October 2026 6 min read

Érythème infectieux (Parvovirus B19)

Introduction

Erythema infectiosum is a benign viral infection caused by parvovirus B19. It mainly affects children but can also occur in adults. It typically presents as a characteristic skin rash, often preceded by mild general symptoms. In most cases, it clears up on its own.

Symptoms

  • Bright red rash on the cheeks, giving a ‘slapped cheek’ appearance
  • Maculopapular rash on the trunk and limbs
  • Sometimes a lacy, net-like pattern on the skin
  • Mild or no fever
  • Fatigue, headache
  • Joint pain (especially in adults)
  • Possible mild itching
  • Mild respiratory symptoms in the early phase

Causes

Infection with parvovirus B19
Respiratory transmission (droplets)
Possible transmission through close contact or at school
Incubation period
about 1 to 3 weeks
Most contagious before the rash appears

Diagnosis

  1. Diagnosis is mainly clinical
  2. Often occurs in outbreaks (schools, communal settings)
  3. Viral serology if the diagnosis is uncertain
  4. Blood PCR reserved for particular situations: pregnancy weakened immune system unexplained anaemia
  5. pregnancy
  6. weakened immune system
  7. unexplained anaemia

Treatments

Fever-reducing medicines if there is a fever
Painkillers for joint pain
Antihistamines if itchy
Rest
Adequate fluid intake
No need to stay off school once the rash has appeared
No specific dermatological technology indicated
Simple clinical follow-up in uncomplicated forms

Management

Dermatological or paediatric care depending on age

Particular monitoring for: pregnant women patients with a weakened immune system patients with chronic anaemia

pregnant women

patients with a weakened immune system

patients with chronic anaemia

Reassuring information for the patient and those around them

Frequently asked questions

Consultation for erythema infectiosum (parvovirus B19)

Consultation with a confirmed diagnosis and a written treatment plan.

Call Book an appointment